Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional) | RFA DK 21 026

Opportunity Information: Apply for RFA DK 21 026

The Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) funding opportunity (RFA-DK-21-026) is an NIH/NIDDK P30 center grant designed to strengthen and coordinate digestive and liver disease research by supporting shared infrastructure, services, and resources that multiple investigators can use. Rather than funding a single research project, the program is built around the "core center" model: a funded institution creates centralized cores (shared facilities, technical services, expertise, and administrative support) that make ongoing basic and clinical research more efficient, more collaborative, and more innovative. The overarching goal is to bring investigators together in a way that improves communication across disciplines, encourages new scientific partnerships, and increases the overall impact and productivity of NIDDK-relevant digestive and liver disease research at the applicant organization. Clinical trials are optional under this FOA, meaning the center may support work that includes clinical trials, but a clinical trial is not required.

A key requirement is that each proposed DDRCC must be organized around a clear central theme. This theme should reflect the main scientific focus of the participating center investigators and should align squarely with the primary mission of NIDDK in digestive and/or liver diseases. The FOA also emphasizes that the theme should not fall primarily under the mission areas typically supported by other NIH Institutes or Centers as the main funder. In practical terms, applicants are expected to demonstrate that they already have a strong base of funded, high-quality digestive or liver disease research and that the proposed cores will add value by providing cost-effective shared resources, fostering synergy across labs and clinics, and helping generate new research directions that individual projects could not as easily pursue alone.

The opportunity is offered by the National Institutes of Health (NIH), specifically through NIDDK, and uses the grant funding instrument under a discretionary funding category. It is listed under CFDA 93.847 (Food and Nutrition, Health). Eligible applicant organizations are broad and include many domestic public and private entities: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (as long as they are not higher education institutions when applying in that nonprofit category); for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly notes additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with certain community-based and faith-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Federally recognized Native American tribal governments are eligible, and certain non-federally recognized tribal organizations/governments are also included in the eligibility list.

Foreign participation is clearly restricted. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) foreign institutions are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed. In other words, this opportunity is intended to support U.S.-based center infrastructure without foreign organizational components.

From an administrative perspective, the FOA was created on 2021-09-03 and listed an original closing date of 2023-06-08. The public synopsis does not provide an award ceiling amount or the expected number of awards, which typically means applicants would need to consult the full FOA and NIH budget guidance for detailed limits, allowable costs, and any program-specific caps or expectations. Overall, the program is best understood as institutional support for a coordinated digestive and liver disease research ecosystem: a themed center with shared cores that lower barriers to cutting-edge methods, improve study rigor and efficiency, and spark cross-disciplinary collaborations that advance NIDDK-priority science.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2021-09-03.
• Applicants must submit their applications by 2023-06-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DK 21 026

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