Opportunity Information: Apply for RFA DK 21 026
The Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) funding opportunity (RFA-DK-21-026) is an NIH/NIDDK P30 center grant designed to strengthen and coordinate digestive and liver disease research by supporting shared infrastructure, services, and resources that multiple investigators can use. Rather than funding a single research project, the program is built around the "core center" model: a funded institution creates centralized cores (shared facilities, technical services, expertise, and administrative support) that make ongoing basic and clinical research more efficient, more collaborative, and more innovative. The overarching goal is to bring investigators together in a way that improves communication across disciplines, encourages new scientific partnerships, and increases the overall impact and productivity of NIDDK-relevant digestive and liver disease research at the applicant organization. Clinical trials are optional under this FOA, meaning the center may support work that includes clinical trials, but a clinical trial is not required.
A key requirement is that each proposed DDRCC must be organized around a clear central theme. This theme should reflect the main scientific focus of the participating center investigators and should align squarely with the primary mission of NIDDK in digestive and/or liver diseases. The FOA also emphasizes that the theme should not fall primarily under the mission areas typically supported by other NIH Institutes or Centers as the main funder. In practical terms, applicants are expected to demonstrate that they already have a strong base of funded, high-quality digestive or liver disease research and that the proposed cores will add value by providing cost-effective shared resources, fostering synergy across labs and clinics, and helping generate new research directions that individual projects could not as easily pursue alone.
The opportunity is offered by the National Institutes of Health (NIH), specifically through NIDDK, and uses the grant funding instrument under a discretionary funding category. It is listed under CFDA 93.847 (Food and Nutrition, Health). Eligible applicant organizations are broad and include many domestic public and private entities: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (as long as they are not higher education institutions when applying in that nonprofit category); for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly notes additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with certain community-based and faith-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. Federally recognized Native American tribal governments are eligible, and certain non-federally recognized tribal organizations/governments are also included in the eligibility list.
Foreign participation is clearly restricted. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) foreign institutions are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed. In other words, this opportunity is intended to support U.S.-based center infrastructure without foreign organizational components.
From an administrative perspective, the FOA was created on 2021-09-03 and listed an original closing date of 2023-06-08. The public synopsis does not provide an award ceiling amount or the expected number of awards, which typically means applicants would need to consult the full FOA and NIH budget guidance for detailed limits, allowable costs, and any program-specific caps or expectations. Overall, the program is best understood as institutional support for a coordinated digestive and liver disease research ecosystem: a themed center with shared cores that lower barriers to cutting-edge methods, improve study rigor and efficiency, and spark cross-disciplinary collaborations that advance NIDDK-priority science.Apply for RFA DK 21 026
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2021-09-03.
- Applicants must submit their applications by 2023-06-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs) - Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) (RFA-DK-21-026)
What is the Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs) opportunity?
This is an NIH/NIDDK P30 center grant funding opportunity (RFA-DK-21-026) designed to strengthen and coordinate digestive and liver disease research by supporting shared infrastructure, services, and resources that multiple investigators can use within an institution.
What does a P30 "core center" grant fund?
A P30 core center grant supports centralized "cores" (shared facilities, technical services, expertise, and administrative support) that make ongoing basic and clinical research more efficient, collaborative, and innovative. It is not intended to fund a single stand-alone research project.
What is the main goal of a DDRCC?
The overarching goal is to bring investigators together to improve communication across disciplines, encourage new scientific partnerships, and increase the overall impact and productivity of NIDDK-relevant digestive and liver disease research at the applicant organization.
Does this opportunity require a clinical trial?
No. Clinical trials are optional under this funding opportunity. The center may support work that includes clinical trials, but a clinical trial is not required.
Is a central scientific theme required for a DDRCC?
Yes. Each proposed DDRCC must be organized around a clear central theme that reflects the main scientific focus of the participating investigators and aligns with NIDDK's primary mission in digestive and/or liver diseases.
How should the central theme relate to NIH Institute/Center missions?
The theme should align squarely with the primary mission of NIDDK in digestive and/or liver diseases and should not fall primarily under mission areas typically supported by other NIH Institutes or Centers as the main funder.
What kind of research environment is expected from applicants?
Applicants are expected to demonstrate an existing strong base of funded, high-quality digestive or liver disease research. The proposed cores should add value by providing cost-effective shared resources, fostering synergy across labs and clinics, and enabling new research directions that individual projects could not easily pursue alone.
Who is the funding agency for this opportunity?
The opportunity is offered by the National Institutes of Health (NIH), specifically through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the funding instrument and program type?
The funding instrument is a grant, and it is a discretionary funding opportunity. The mechanism is a P30 center grant focused on shared resources and infrastructure.
What is the CFDA number listed for this opportunity?
The listing identifies CFDA 93.847 (Food and Nutrition, Health).
Which organizations are eligible to apply?
Eligible applicants include a wide range of domestic U.S. entities, including: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (as long as they are not higher education institutions when applying in that nonprofit category); for-profit organizations (other than small businesses); and small businesses.
Are institutions serving specific communities explicitly included in eligibility?
Yes. The eligibility list explicitly includes organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are tribal governments or tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible. The eligibility list also includes certain non-federally recognized tribal organizations and governments.
Are community-based and faith-based organizations eligible?
The FOA explicitly notes that certain community-based and faith-based organizations are included among eligible applicant types.
Are federal agencies or U.S. territories eligible?
Yes. The eligibility list includes eligible federal agencies, regional organizations, and U.S. territories or possessions.
Can foreign organizations apply for this funding?
No. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) foreign institutions are not eligible to apply.
Can a U.S. organization include a non-U.S. component or foreign component in the application?
No. Non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed.
What kinds of resources are DDRCCs meant to provide?
DDRCCs are intended to provide shared infrastructure and centralized cores, such as shared facilities, technical services, specialized expertise, and administrative support that multiple investigators can access to improve efficiency and collaboration.
How does a DDRCC improve research productivity and collaboration?
By centralizing resources and support services, DDRCCs reduce duplication, lower barriers to using cutting-edge methods, improve study rigor and efficiency, and create a structured environment that encourages cross-disciplinary communication and partnerships.
Does the public synopsis provide an award ceiling or expected number of awards?
No. The public synopsis does not provide an award ceiling amount or the expected number of awards. Applicants would generally need to consult the full FOA and NIH budget guidance for detailed limits and expectations.
When was the funding opportunity created and what closing date is listed?
The FOA was created on 2021-09-03 and lists an original closing date of 2023-06-08.
What is the practical purpose of this program in one sentence?
The program provides institutional support for a coordinated, themed digestive and liver disease research ecosystem by funding shared cores that strengthen NIDDK-priority science across multiple investigators.
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