Opportunity Information: Apply for RFA AT 24 005
The NIH is soliciting applications for an R24 research resource grant titled "Research Resource for Systematic Reviews of Complementary and Integrative Health (Clinical Trial Not Allowed)" under opportunity number RFA-AT-24-005 (CFDA 93.213). The overall purpose is to fund an infrastructure-style resource that supports evidence synthesis in complementary and integrative health by sustaining and improving a database of controlled trials. Rather than funding new clinical studies, this award is focused on organizing, curating, and continuously updating the research evidence base so that systematic reviewers, researchers, clinicians, policy makers, and the public can more easily find and use high-quality information about complementary and integrative health interventions.
A central expectation is that the funded team will operate a reliable database of controlled trials of complementary and integrative health interventions. Applicants are expected to clearly explain their plan to either build a database from the ground up, maintain an existing database, or convert an existing database into a form that better serves systematic review needs. The application should spell out practical details such as how studies will be identified and screened, what data elements will be captured, how records will be structured and indexed, what quality control procedures will be used, and how updates will be handled over the full period of the award. Just as important, the team needs to describe how the database will be kept current, including ongoing surveillance of the literature and an update workflow that prevents the resource from becoming outdated.
Beyond simply housing trial records, the initiative emphasizes broader reach and usability. The resource is expected to increase outreach, access, and availability to a wider scientific community, as well as to public audiences and policy makers. In practice, this means the award is not only about technical database management, but also about dissemination and user engagement. Strong proposals would typically address how users will discover the resource, how the interface and outputs will support different audiences, what forms of access will be provided (for example, searchable web access and downloadable exports), and how the team will promote adoption and appropriate use of the database in systematic reviews and evidence-informed decision making.
The opportunity also requires active evidence synthesis work in addition to database maintenance. The funded resource should update multiple systematic reviews with current evidence and conduct new systematic reviews each year. Review topics must align with NCCIH priorities as described in the NCCIH Strategic Plan 2021-2025, with special emphasis on whole person research and multi-component complementary and integrative health interventions. Within a whole person health framework, the NIH is particularly interested in topics that examine interconnected biological and behavioral systems, evaluate multicomponent intervention packages or therapeutic systems, and assess outcomes that span multiple organs or systems rather than focusing narrowly on a single endpoint. The intent is to support systematic reviews that are methodologically rigorous and relevant to how complementary and integrative approaches are often delivered in real-world settings.
Eligibility is broad and includes many types of U.S.-based organizations: state, county, and local governments; special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education where specified); for-profit organizations other than small businesses; and small businesses. The announcement also explicitly highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI), along with faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Foreign organizations and foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible. However, foreign components are allowed when they meet the NIH definition under the NIH Grants Policy Statement, which typically means specific, well-justified international elements can be included within an otherwise eligible U.S. application.
Administratively, this is a discretionary grant mechanism using the NIH R24 activity code, and it is explicitly labeled "Clinical Trial Not Allowed," reinforcing that the work should center on research resources and systematic review activities rather than initiating clinical trials. The opportunity was created on July 13, 2023, with an original closing date of August 31, 2023, according to the source information provided. Award ceiling and expected number of awards are not specified in the provided listing, so applicants would normally look to the full NIH notice and related budget guidance for details on funding levels and project period expectations.Apply for RFA AT 24 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Resource for Systematic Reviews of Complementary and Integrative Health (R24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213.
- This funding opportunity was created on 2023-07-13.
- Applicants must submit their applications by 2023-08-31. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
1) What is this NIH funding opportunity?
This opportunity is an NIH R24 research resource grant titled "Research Resource for Systematic Reviews of Complementary and Integrative Health (Clinical Trial Not Allowed)" under opportunity number RFA-AT-24-005 (CFDA 93.213). It supports infrastructure that strengthens evidence synthesis in complementary and integrative health by sustaining and improving a database of controlled trials and producing systematic reviews.
2) What is the overall purpose of the grant?
The purpose is to fund an infrastructure-style resource that helps people find and use high-quality evidence about complementary and integrative health interventions. The emphasis is on organizing, curating, and continuously updating the research evidence base so systematic reviewers, researchers, clinicians, policy makers, and the public can access controlled trial information more easily.
3) Is this grant intended to fund new clinical trials?
No. The funding announcement is explicitly labeled "Clinical Trial Not Allowed." The work should focus on building and operating a research resource (a controlled trials database) and conducting evidence synthesis (systematic reviews), not initiating or running clinical trials.
4) What activity code and grant mechanism does NIH use for this opportunity?
This is a discretionary NIH grant using the R24 activity code, which is generally used for research resources and related infrastructure-oriented projects.
5) What types of work are expected to be supported?
The opportunity supports two major work streams: (1) operating and improving a reliable database of controlled trials of complementary and integrative health interventions, and (2) conducting evidence synthesis by updating multiple systematic reviews and completing new systematic reviews each year.
6) What kind of database is NIH expecting the funded team to operate?
The funded team is expected to operate a database of controlled trials focused on complementary and integrative health interventions. The database is intended to be dependable, systematically curated, and kept current so it can support systematic review needs.
7) Do applicants have to build a new database, or can they use an existing one?
Applicants may propose to build a database from the ground up, maintain an existing database, or convert an existing database into a form that better supports systematic reviews. The key expectation is that the approach is clearly explained and results in a database that serves evidence synthesis effectively.
8) What operational details should an application describe for the database?
Applications are expected to describe practical implementation details, including how studies will be identified and screened, what data elements will be captured, how records will be structured and indexed, what quality control procedures will be used, and how updates will be handled across the full award period.
9) How important is keeping the database current?
Keeping the resource current is a central expectation. The application should explain ongoing surveillance of the literature and an update workflow designed to prevent the database from becoming outdated over the full project period.
10) Is the project only about technical database maintenance?
No. The opportunity also emphasizes reach and usability. In addition to database operations, the resource is expected to improve outreach, access, and availability for the scientific community, the public, and policy makers. Dissemination and user engagement are part of the expectation.
11) Who are the intended users of the resource?
The resource is intended to support systematic reviewers, researchers, clinicians, policy makers, and the general public by making controlled trial evidence in complementary and integrative health easier to find and use.
12) What kinds of access methods or outputs are expected?
The description highlights usability for different audiences and notes examples such as searchable web access and downloadable exports. Strong proposals would typically address how users will discover the resource, how the interface and outputs will support different audiences, and what forms of access will be provided.
13) What evidence synthesis activities are required beyond maintaining the database?
The funded resource is expected to update multiple systematic reviews with current evidence and to conduct new systematic reviews each year, in addition to database maintenance and improvements.
14) How should systematic review topics be selected?
Systematic review topics must align with NCCIH priorities as described in the NCCIH Strategic Plan 2021-2025. The opportunity places special emphasis on whole person research and multi-component complementary and integrative health interventions.
15) What does "whole person" emphasis mean in the context of this opportunity?
Within a whole person health framework, NIH is particularly interested in topics that examine interconnected biological and behavioral systems, evaluate multicomponent intervention packages or therapeutic systems, and assess outcomes spanning multiple organs or systems rather than focusing narrowly on a single endpoint.
16) What types of organizations are eligible to apply?
Eligibility is broad for U.S.-based organizations and includes state, county, and local governments; special district governments; independent school districts; public and state-controlled and private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits (501(c)(3) and non-501(c)(3), excluding institutions of higher education where specified); for-profit organizations other than small businesses; and small businesses.
17) Are any specific institution types explicitly highlighted as eligible?
Yes. The announcement explicitly highlights eligible applicant categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI). It also mentions faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
18) Are foreign organizations eligible to apply?
No. Foreign organizations and foreign institutions are not eligible to apply.
19) Can a U.S. organization include non-U.S. components in the application?
Non-U.S. components of U.S. organizations are not eligible. However, foreign components are allowed when they meet the NIH definition under the NIH Grants Policy Statement, meaning specific, well-justified international elements can be included within an otherwise eligible U.S. application.
20) What is the opportunity number and CFDA listing?
The opportunity number is RFA-AT-24-005 and the CFDA number provided is 93.213.
21) When was this opportunity created and what is the closing date listed?
The opportunity was created on July 13, 2023, and the source information provided lists an original closing date of August 31, 2023.
22) Does the provided listing specify an award ceiling or the expected number of awards?
No. The provided listing does not specify an award ceiling or the expected number of awards. Applicants would typically consult the full NIH notice and related budget guidance for funding levels and project period expectations.
23) What is the main difference between this resource grant and a typical research project grant?
Based on the description provided, this R24 is oriented toward sustaining and improving a shared research resource (a controlled trials database) and producing systematic reviews, rather than generating new primary clinical trial data.
24) What makes a proposal "strong" according to the description provided?
Strong proposals would address both the operational and user-facing sides of the resource: a clear plan for study identification, screening, data capture, structuring/indexing, quality control, and ongoing updates, along with outreach and dissemination plans that improve discoverability, usability for multiple audiences, and adoption in systematic reviews and evidence-informed decision making.
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