Opportunity Information: Apply for PAR 18 951
The NIH grant opportunity "Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)" (Funding Opportunity Number PAR-18-951) is designed to fund collaborative, translational research projects that can be carried out in partnership with the NIH Clinical Center. The central purpose is to help move promising basic biological discoveries toward practical clinical use, with an emphasis on research that can improve human health. Projects are expected to be strongly aligned with the scientific priorities of the participating NIH Institutes and Centers and to show clear potential to deepen understanding of significant disease processes or to generate new or improved therapeutics, diagnostics, or prevention strategies. Because this is a U01 cooperative agreement, applicants should anticipate an active partnership with NIH staff during the conduct of the work, rather than a hands-off funding relationship. The announcement also notes that clinical trials are optional, meaning applicants may propose either trial or non-trial clinical/translational studies if they fit the program goals.
This opportunity falls under the discretionary funding category and uses the cooperative agreement funding instrument (U01). It is associated with NIH and spans multiple activity areas that include health, education, and social services-related domains as reflected in the listed CFDA numbers (including, among others, 93.121, 93.172, 93.173, 93.242, 93.273, 93.279, 93.313, 93.393-93.399, 93.837-93.839, 93.846, 93.853, 93.865, and 93.867). The opportunity was created on 2018-10-05, and the original closing date listed in the source data is 2021-04-15. The stated award ceiling is $500,000, which signals the program is intended to support substantial, but targeted, collaborative projects rather than very large center-scale efforts. The source data does not specify the number of expected awards.
Eligibility is broad and intentionally inclusive, covering a wide range of potential applicants who can contribute to meaningful translational work. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations both with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and several categories of tribal entities, including federally recognized Native American tribal governments, public housing authorities/Indian housing authorities, and Native American tribal organizations that are not federally recognized tribal governments. The announcement further highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-domestic (non-U.S.) entities (foreign organizations), U.S. territories or possessions, and Indian/Native American tribal governments that are not federally recognized. Taken together, this indicates NIH is encouraging participation from diverse institutional settings, including underserved and minority-serving institutions and organizations outside the United States, as long as the proposed collaboration and research plan fit NIH priorities and the NIH Clinical Center collaboration model.
In practical terms, applicants considering this opportunity should frame their proposals around a clear translational pathway: a strong biological rationale or discovery foundation, a defined clinical or human health application, and a realistic plan for how the collaboration with the NIH Clinical Center will accelerate progress. Competitive projects would typically be those that are not only scientifically rigorous, but also positioned to produce actionable clinical insights, generate evidence supporting a new intervention or diagnostic approach, or clarify mechanisms of disease in ways that directly inform patient care and future clinical development.Apply for PAR 18 951
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.313, 93.321, 93.393, 93.394, 93.395, 93.396, 93.399, 93.837, 93.838, 93.839, 93.846, 93.853, 93.865, 93.867.
- This funding opportunity was created on 2018-10-05.
- Applicants must submit their applications by 2021-04-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the NIH funding opportunity PAR-18-951?
PAR-18-951 is an NIH grant opportunity titled "Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)." It supports collaborative, translational research projects conducted in partnership with the NIH Clinical Center, with the goal of moving promising basic biological discoveries toward practical clinical use to improve human health.
What is the main goal of this program?
The central purpose is to accelerate translation of basic discoveries into clinical applications. Projects should show clear potential to deepen understanding of important disease processes and/or to generate new or improved therapeutics, diagnostics, or prevention strategies.
What kind of research does the opportunity support?
The opportunity supports collaborative, translational research that can be carried out with the NIH Clinical Center. The emphasis is on research that can lead to real-world clinical impact, such as actionable clinical insights, evidence for a new intervention or diagnostic approach, or clearer understanding of disease mechanisms that informs patient care and future development.
Does the project have to involve a clinical trial?
No. Clinical trials are optional under this opportunity. Applicants may propose either clinical trial projects or non-trial clinical/translational studies, as long as the work fits the program goals and the collaboration model with the NIH Clinical Center.
What does "U01 cooperative agreement" mean for applicants?
This award uses a U01 cooperative agreement mechanism, which means applicants should expect an active partnership with NIH staff during the conduct of the work. It is not a hands-off funding relationship; NIH staff are anticipated to have an engaged role consistent with a cooperative agreement.
What organization is offering this opportunity?
The opportunity is associated with the National Institutes of Health (NIH) and is designed around collaboration with the NIH Clinical Center.
How important is alignment with NIH priorities?
Projects are expected to be strongly aligned with the scientific priorities of the participating NIH Institutes and Centers. Proposals should clearly show how the aims match those priorities while also fitting the NIH Clinical Center collaboration model.
What is the maximum award amount (award ceiling)?
The stated award ceiling is $500,000. This suggests the program is intended to support substantial but targeted collaborative projects rather than very large center-scale efforts.
How many awards will NIH make under this funding opportunity?
The source information provided does not specify the number of expected awards.
When was this funding opportunity created, and what is the closing date listed in the source data?
The opportunity was created on 2018-10-05. The original closing date listed in the source data is 2021-04-15.
What is the funding instrument and funding category?
This opportunity uses the cooperative agreement funding instrument (U01) and falls under the discretionary funding category.
Who is eligible to apply?
Eligibility is broad and includes a wide range of applicant types. Eligible applicants include:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations with 501(c)(3) status (other than institutions of higher education)
- Nonprofit organizations without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations other than small businesses
- Small businesses
- Tribal entities, including federally recognized Native American tribal governments
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than federally recognized tribal governments)
Are minority-serving institutions specifically included as eligible applicants?
Yes. The opportunity highlights multiple minority-serving institution categories as eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Can faith-based or community-based organizations apply?
Yes. Faith-based or community-based organizations are explicitly included among the eligible applicant types mentioned in the opportunity information.
Are federal agencies or regional organizations eligible?
Yes. The opportunity information mentions eligible federal agencies and regional organizations among the eligible applicant types.
Can non-U.S. organizations apply?
Yes. Non-domestic (non-U.S.) entities (foreign organizations) are listed as eligible applicant types in the opportunity information provided.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among the eligible applicant types highlighted in the opportunity information.
What types of projects are likely to be competitive?
Competitive projects would typically be scientifically rigorous and built around a clear translational pathway: a strong biological rationale or discovery foundation, a defined clinical or human health application, and a realistic plan showing how collaboration with the NIH Clinical Center will accelerate progress toward clinical impact.
What should applicants emphasize in their proposal narrative?
Applicants should frame the proposal around (1) the underlying biological discovery or rationale, (2) the intended human health or clinical application, (3) the expected value of partnering with the NIH Clinical Center, and (4) how the work aligns with the scientific priorities of the participating NIH Institutes and Centers.
What activity areas are associated with this opportunity?
The opportunity spans multiple activity areas that include health, education, and social services-related domains, as reflected in the listed CFDA numbers associated with the program.
Which CFDA numbers are associated with this opportunity?
The opportunity references multiple CFDA numbers, including (among others): 93.121, 93.172, 93.173, 93.242, 93.273, 93.279, 93.313, 93.393-93.399, 93.837-93.839, 93.846, 93.853, 93.865, and 93.867.
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| Funding Opportunity |
|---|
| Pre-application: Opportunities for Collaborative Research at the NIH Clinical Center (X02 Clinical Trial Optional) Apply for PAR 18 950 Funding Number: PAR 18 950 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional) Apply for RFA MH 19 400 Funding Number: RFA MH 19 400 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed) Apply for RFA NS 19 006 Funding Number: RFA NS 19 006 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed) Apply for PAR 19 069 Funding Number: PAR 19 069 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| Mentored Research Scientist Development Award (Parent K01 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 084 Funding Number: PA 19 084 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Technology Research Sites (UH2/UH3 Clinical Trial Optional) Apply for RFA AR 19 028 Funding Number: RFA AR 19 028 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| HEAL Initiative: Back Pain Consortium (BACPAC) Research Program: Mechanistic Research Centers (U19 Clinical Trial Optional) Apply for RFA AR 19 026 Funding Number: RFA AR 19 026 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management Center (U24 Clinical Trial Not Allowed) Apply for RFA AR 19 027 Funding Number: RFA AR 19 027 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $3,600,000 |
| HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional) Apply for RFA NS 19 018 Funding Number: RFA NS 19 018 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional) Apply for RFA AT 19 004 Funding Number: RFA AT 19 004 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Tissue Chips to Model Nociception, Addiction, and Overdose (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA TR 19 003 Funding Number: RFA TR 19 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 1630) (UG3/UH3 Clinical Trial Required) Apply for RFA DA 19 035 Funding Number: RFA DA 19 035 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Behavioral Research to Improve MAT: Behavioral and Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R61/R33 Clinical Trial Optional) Apply for RFA AT 19 006 Funding Number: RFA AT 19 006 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) Apply for PA 19 127 Funding Number: PA 19 127 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed) Apply for PA 19 124 Funding Number: PA 19 124 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 19 126 Funding Number: PA 19 126 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Required) Apply for PA 19 129 Funding Number: PA 19 129 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) Apply for PAR 19 135 Funding Number: PAR 19 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) Apply for PAR 19 163 Funding Number: PAR 19 163 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| HIV/AIDS Clinical Trials Networks Laboratory Centers (UM1 Clinical Trial Required) Apply for RFA AI 19 001 Funding Number: RFA AI 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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