Opportunity Information: Apply for PAR 23 065
The NIAID Resource-Related Research Projects (R24 Clinical Trial Not Allowed) funding opportunity (PAR-23-065) is a National Institutes of Health discretionary grant designed to support investigator-initiated projects that build, enhance, or coordinate research resources that materially help ongoing, high-priority NIAID-supported work. The central idea is not to fund a standard hypothesis-driven research project, but to fund a shared resource that solves a clear need for coordination, support, infrastructure, or access that multiple NIAID-relevant projects depend on. NIAID signals that this R24 mechanism is expected to be used infrequently and mainly when other NIAID support mechanisms are not a good fit. In other words, applicants should be prepared to justify why an R24 resource award is the right tool and why the resource would have outsized value for already-funded efforts.
The resource proposed under this announcement must provide significant benefit to currently funded, high-priority projects that need additional coordination and support in the areas covered by NIAID. While the FOA also notes that, in rare circumstances, an R24 may be used to develop a brand-new resource for the broader NIAID scientific community, the emphasis is clearly on strengthening and enabling work that is already underway and considered high priority. A competitive application would typically describe the user base, the concrete gaps the resource addresses, how the resource will be accessed and governed, and how it will measurably improve productivity, standardization, interoperability, or impact across supported projects. Because this is labeled "Clinical Trial Not Allowed," the award cannot be used to conduct clinical trials; the activities need to be resource-related and supportive rather than interventional clinical testing.
Scientifically, the resource must align with the NIAID mission. That includes research relevant to the biology, pathogenesis, and host response to microbes (explicitly including HIV), as well as the mechanisms of normal immune function and immune dysfunction that lead to autoimmunity, immunodeficiency, allergy, asthma, and transplant rejection. It also includes translational research-oriented resources that accelerate development of vaccines, therapeutics, and diagnostics aimed at preventing and treating infectious, immune-mediated, and allergic diseases. In practical terms, resources could involve coordinated cores, shared platforms, data or specimen infrastructure, harmonized methods, or other community-enabling capabilities, as long as the work stays squarely within NIAID programmatic priorities and is positioned as a benefit multiplier for multiple projects rather than a single lab.
Eligibility is broad across U.S.-based organizations and governmental units. Eligible applicants listed include state, county, city or township governments, special district governments, and independent school districts; public and state-controlled institutions of higher education and private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses) as well as small businesses; and other categories. The FOA also highlights that eligible applicants include institutions and organizations such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, regional organizations, and U.S. territories or possessions. At the same time, it draws clear boundaries around foreign participation: non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" as defined by the NIH Grants Policy Statement are allowed, meaning a U.S. applicant may include certain foreign elements in the project when justified and compliant with NIH policy.
From the opportunity metadata, this is a grant (funding instrument type: Grant) in the health category, associated with CFDA number 93.855. The original closing date listed is 2026-01-07, and the posting/creation date is 2022-11-23. The award ceiling and expected number of awards are not specified in the provided source data, which usually means applicants should look to the full FOA and NIH budget policy guidance for expectations about budget scope, justification requirements, and any institute-specific limits or preferences.
Overall, this opportunity is best read as a targeted mechanism for building or coordinating high-value research resources that multiple NIAID-relevant projects need, especially where stronger shared infrastructure or coordination would speed progress, improve rigor and standardization, or extend the reach of NIAID investments. Applicants should be prepared to make a strong case that the proposed resource is truly enabling, broadly beneficial to priority work, and not simply a rebranded research project or a clinical trial.Apply for PAR 23 065
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIAID Resource-Related Research Projects (R24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on 2022-11-23.
- Applicants must submit their applications by 2026-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NIAID Resource-Related Research Projects (R24, Clinical Trial Not Allowed) - PAR-23-065
What is this funding opportunity?
This opportunity is the NIAID Resource-Related Research Projects (R24 Clinical Trial Not Allowed) funding opportunity announcement (FOA) PAR-23-065. It is an NIH discretionary grant intended to support investigator-initiated projects that build, enhance, or coordinate research resources that materially help ongoing, high-priority NIAID-supported work.
What is the main purpose of an R24 under this FOA?
The core purpose is to fund a shared resource (such as coordination, support infrastructure, or access platforms) that multiple NIAID-relevant projects depend on. It is not meant to fund a standard hypothesis-driven research project; it is meant to solve a clear resource need that boosts the productivity, rigor, or impact of multiple projects.
Is this intended to fund a traditional research project?
No. The central idea is to support a resource-related project rather than a conventional, hypothesis-driven research study. Applications should emphasize how the proposed resource enables and strengthens multiple high-priority NIAID-supported efforts.
How does NIAID view the R24 mechanism for this program?
NIAID indicates that this R24 mechanism is expected to be used infrequently and primarily when other NIAID support mechanisms are not a good fit. Applicants should be prepared to justify why an R24 resource award is the appropriate mechanism and why it delivers outsized value for already-funded, high-priority work.
Who should benefit from the proposed resource?
The proposed resource must provide significant benefit to currently funded, high-priority projects in areas covered by NIAID. The emphasis is on strengthening and enabling work that is already underway and considered high priority.
Can this FOA support development of a brand-new resource?
Yes, but only in rare circumstances. The FOA notes that an R24 may sometimes be used to develop a new resource for the broader NIAID scientific community; however, the clear emphasis is on resources that support currently funded, high-priority NIAID-supported projects.
What kinds of activities or resources might be supported?
Examples described at a high level include coordinated cores, shared platforms, data or specimen infrastructure, harmonized methods, and other community-enabling capabilities. The key requirement is that the activity is resource-related, aligns with NIAID priorities, and acts as a benefit multiplier across multiple projects.
What should a competitive application typically describe?
Based on the FOA summary provided, a competitive application would typically describe the user base, the specific gaps the resource addresses, how the resource will be accessed, how it will be governed, and how it will measurably improve productivity, standardization, interoperability, or impact across supported projects.
Are clinical trials allowed under this award?
No. This FOA is labeled "Clinical Trial Not Allowed," which means the award cannot be used to conduct clinical trials. Supported work should be resource-related and supportive rather than interventional clinical testing.
What scientific areas need to align with the NIAID mission?
The resource must align with NIAID mission areas, including research relevant to the biology, pathogenesis, and host response to microbes (explicitly including HIV), and mechanisms of normal immune function and immune dysfunction leading to autoimmunity, immunodeficiency, allergy, asthma, and transplant rejection. It also includes translational research-oriented resources that accelerate development of vaccines, therapeutics, and diagnostics for infectious, immune-mediated, and allergic diseases.
Does the FOA emphasize translational resource development?
Yes. The description explicitly includes translational research-oriented resources that accelerate development of vaccines, therapeutics, and diagnostics aimed at prevention and treatment of infectious, immune-mediated, and allergic diseases, as long as the activities remain resource-related and within NIAID programmatic priorities.
What is the key positioning applicants should avoid?
Applicants should avoid presenting a standard research project as a resource project. The opportunity is positioned for shared infrastructure, coordination, and access that broadly enables multiple NIAID-relevant projects, rather than work that primarily advances a single lab's research agenda.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and governmental units. Eligible applicants include (among others) state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses) and small businesses; and other categories listed in the FOA.
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The FOA highlights eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; and U.S. territories or possessions.
Are foreign organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply under the information provided.
Can a U.S. organization include a non-U.S. component as the applicant?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are any foreign activities allowed at all?
Yes. While non-U.S. entities cannot apply and non-domestic components of U.S. organizations cannot apply, "foreign components" (as defined by the NIH Grants Policy Statement) are allowed when included by a U.S. applicant and when justified and compliant with NIH policy.
What is the funding instrument type and category?
The funding instrument type is a Grant, and the opportunity is in the health category.
What is the associated CFDA number?
The opportunity is associated with CFDA number 93.855.
What is the listed closing date?
The original closing date listed in the provided metadata is 2026-01-07.
When was this opportunity posted/created?
The posting/creation date provided is 2022-11-23.
Is there an award ceiling listed?
No. The award ceiling is not specified in the provided source data.
Is the expected number of awards listed?
No. The expected number of awards is not specified in the provided source data.
What should applicants do given the lack of ceiling and award count in the provided data?
Because the award ceiling and expected number of awards are not specified here, applicants should rely on the full FOA and NIH budget policy guidance for expectations about budget scope, justification requirements, and any institute-specific limits or preferences.
What is the simplest way to describe a strong fit for this FOA?
A strong fit is a project that builds, enhances, or coordinates a shared research resource that clearly fills a coordination/support/infrastructure/access gap and measurably improves the productivity, standardization, interoperability, or impact of multiple ongoing, high-priority NIAID-supported projects, without conducting clinical trials.
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