Opportunity Information: Apply for PA 21 264
The Agency for Healthcare Research and Quality (AHRQ), part of the U.S. Department of Health and Human Services, is offering a discretionary grant opportunity titled "Large Health Services Research Demonstration and Dissemination Projects for Prevention of Healthcare-Associated Infections (R18)." The program is listed under Funding Opportunity Number PA-21-264 and falls within the health funding activity category (CFDA/Assistance Listing 93.226). The central purpose of this announcement is to support large-scale health services research projects that do more than study a problem in theory: applicants are expected to demonstrate and spread practical strategies that prevent and reduce healthcare-associated infections (HAIs) in real-world healthcare settings. In other words, the focus is on applied work that can be implemented, tested at meaningful scale, and then disseminated so that effective approaches can be adopted more broadly.
This FOA specifically emphasizes "demonstration and dissemination" through the R18 mechanism, which generally aligns with projects designed to produce actionable evidence and implementation-ready lessons rather than early-stage exploratory research. The announcement signals that AHRQ is looking for projects that address strategies and approaches to HAI prevention and reduction, and it notes that the FOA outlines broad areas of HAI research that are eligible for support. While the provided source text does not list the individual topic areas, the framing makes clear that AHRQ is interested in health services research perspectives on infection prevention, such as how care is organized and delivered, how clinical and operational practices can be improved, and how successful interventions can be replicated and sustained across different healthcare environments.
A wide range of applicants are eligible, which is consistent with the goal of driving practical change across the healthcare system. Eligible entities include state, county, and city or township governments; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized as tribal governments; and nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education in the nonprofit category specified). This broad eligibility opens the door for partnerships among public health agencies, hospital systems, academic research groups, community-based nonprofits, and tribal organizations, all of which may have distinct roles in testing and spreading HAI prevention practices.
The opportunity was created on June 15, 2021, and the original closing date is May 26, 2025, indicating a multi-year window during which AHRQ intends to accept applications under this program announcement. The listing shows an expected 100 awards, suggesting relatively substantial planned funding activity over the life of the announcement. The award ceiling is shown as 0, which typically means a specific maximum is not stated in the summary field provided here and that applicants should rely on the full FOA text for any budget limits, project period expectations, or other cost-related constraints that may apply.
Overall, PA-21-264 is a funding opportunity aimed at accelerating the adoption of effective HAI prevention strategies through large health services research projects that demonstrate what works in practice and actively disseminate results so they can be implemented elsewhere. The intent is not only to generate findings, but to support the real-world uptake of proven approaches that reduce infections acquired in healthcare settings, improving patient safety and healthcare quality across a variety of organizations and jurisdictions.Apply for PA 21 264
- The Department of Health and Human Services, Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "Large Health Services Research Demonstration and Dissemination Projects for Prevention of Healthcare-Associated Infections (R18)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226.
- This funding opportunity was created on Jun 15, 2021.
- Applicants must submit their applications by May 26, 2025. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 100 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Large Health Services Research Demonstration and Dissemination Projects for Prevention of Healthcare-Associated Infections (R18)."
Which agency is offering this funding opportunity?
The funding is offered by the Agency for Healthcare Research and Quality (AHRQ), which is part of the U.S. Department of Health and Human Services.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-21-264.
What is the Assistance Listing (CFDA) number for this program?
The Assistance Listing (CFDA) number is 93.226.
What type of grant mechanism does this opportunity use?
This opportunity uses the R18 mechanism, which is framed here as supporting large health services research projects with an emphasis on demonstration and dissemination.
What is the main purpose of PA-21-264?
The central purpose is to support large-scale health services research projects that demonstrate practical strategies to prevent and reduce healthcare-associated infections (HAIs) in real-world healthcare settings and then disseminate those strategies so they can be adopted more broadly.
What does "demonstration and dissemination" mean in the context of this FOA?
It means projects are expected to go beyond studying a problem in theory. Applicants are expected to implement and test practical HAI prevention strategies at meaningful scale in real-world settings and actively spread results and implementation-ready lessons so effective approaches can be replicated elsewhere.
Is this opportunity focused on early-stage exploratory research?
No. Based on the description provided, AHRQ is signaling an emphasis on applied, implementation-oriented work that produces actionable evidence and lessons that can be used in practice, rather than early-stage exploratory research.
What kind of research perspective is AHRQ looking for?
The focus is on health services research approaches to HAI prevention and reduction, such as how care is organized and delivered, how clinical and operational practices can be improved, and how effective interventions can be replicated and sustained across different healthcare environments.
What topics are eligible for support under this FOA?
The FOA is described as outlining broad areas of HAI research eligible for support. The specific topic areas are not listed in the provided summary, but the framing emphasizes strategies and approaches for HAI prevention and reduction in real-world settings, along with dissemination of successful approaches.
Who is eligible to apply?
The summary indicates a broad range of eligible applicants, including:
- State governments
- County governments
- City or township governments
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Native American tribal organizations (not federally recognized as tribal governments)
- Nonprofit organizations with 501(c)(3) status (other than institutions of higher education in the specified nonprofit category)
- Nonprofit organizations without 501(c)(3) status (other than institutions of higher education in the specified nonprofit category)
Does this opportunity encourage partnerships across different types of organizations?
Yes. The breadth of eligible entities suggests the program is designed to support practical change across the healthcare system, which can naturally include partnerships among governments, healthcare delivery organizations, academic research teams, nonprofits, and tribal organizations to test and spread HAI prevention practices.
What is the funding activity category for this opportunity?
The opportunity is listed under the health funding activity category.
When was this funding opportunity created?
The opportunity was created on June 15, 2021.
What is the closing date for this opportunity?
The original closing date listed is May 26, 2025.
Does the long open window mean AHRQ plans to accept applications over multiple years?
Yes. The listing shows a multi-year window between the creation date (June 15, 2021) and the original closing date (May 26, 2025), indicating AHRQ intends to accept applications under this program announcement over an extended period.
How many awards are expected under this opportunity?
The listing shows an expected 100 awards.
Is there a stated maximum award amount (award ceiling)?
The award ceiling is shown as 0 in the summary provided. This typically indicates a specific maximum is not stated in that summary field, and applicants should consult the full FOA text for any applicable budget limits or constraints.
Where should applicants look for budget limits, project period expectations, or detailed cost constraints?
Because the award ceiling is not specified in the provided summary, applicants should rely on the full FOA (PA-21-264) for budget limits, project period expectations, and other detailed financial or administrative requirements.
What kind of outcomes does AHRQ appear to be aiming for with this program?
Based on the description, the program is aimed at accelerating real-world uptake of effective HAI prevention strategies by funding projects that both demonstrate what works in practice and disseminate the results so the approaches can be implemented more broadly, improving patient safety and healthcare quality.
What is the overall focus area of the funded projects?
The overall focus is on preventing and reducing infections acquired in healthcare settings (healthcare-associated infections, or HAIs) through large-scale, applied health services research that includes demonstration and dissemination components.
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