Opportunity Information: Apply for PA 21 264
The Agency for Healthcare Research and Quality (AHRQ), part of the U.S. Department of Health and Human Services, is offering a discretionary grant opportunity titled "Large Health Services Research Demonstration and Dissemination Projects for Prevention of Healthcare-Associated Infections (R18)." The program is listed under Funding Opportunity Number PA-21-264 and falls within the health funding activity category (CFDA/Assistance Listing 93.226). The central purpose of this announcement is to support large-scale health services research projects that do more than study a problem in theory: applicants are expected to demonstrate and spread practical strategies that prevent and reduce healthcare-associated infections (HAIs) in real-world healthcare settings. In other words, the focus is on applied work that can be implemented, tested at meaningful scale, and then disseminated so that effective approaches can be adopted more broadly.
This FOA specifically emphasizes "demonstration and dissemination" through the R18 mechanism, which generally aligns with projects designed to produce actionable evidence and implementation-ready lessons rather than early-stage exploratory research. The announcement signals that AHRQ is looking for projects that address strategies and approaches to HAI prevention and reduction, and it notes that the FOA outlines broad areas of HAI research that are eligible for support. While the provided source text does not list the individual topic areas, the framing makes clear that AHRQ is interested in health services research perspectives on infection prevention, such as how care is organized and delivered, how clinical and operational practices can be improved, and how successful interventions can be replicated and sustained across different healthcare environments.
A wide range of applicants are eligible, which is consistent with the goal of driving practical change across the healthcare system. Eligible entities include state, county, and city or township governments; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized as tribal governments; and nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education in the nonprofit category specified). This broad eligibility opens the door for partnerships among public health agencies, hospital systems, academic research groups, community-based nonprofits, and tribal organizations, all of which may have distinct roles in testing and spreading HAI prevention practices.
The opportunity was created on June 15, 2021, and the original closing date is May 26, 2025, indicating a multi-year window during which AHRQ intends to accept applications under this program announcement. The listing shows an expected 100 awards, suggesting relatively substantial planned funding activity over the life of the announcement. The award ceiling is shown as 0, which typically means a specific maximum is not stated in the summary field provided here and that applicants should rely on the full FOA text for any budget limits, project period expectations, or other cost-related constraints that may apply.
Overall, PA-21-264 is a funding opportunity aimed at accelerating the adoption of effective HAI prevention strategies through large health services research projects that demonstrate what works in practice and actively disseminate results so they can be implemented elsewhere. The intent is not only to generate findings, but to support the real-world uptake of proven approaches that reduce infections acquired in healthcare settings, improving patient safety and healthcare quality across a variety of organizations and jurisdictions.Apply for PA 21 264
- The Department of Health and Human Services, Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "Large Health Services Research Demonstration and Dissemination Projects for Prevention of Healthcare-Associated Infections (R18)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226.
- This funding opportunity was created on Jun 15, 2021.
- Applicants must submit their applications by May 26, 2025. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 100 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education.
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